In Yakuza 6, Kazuma Kiryu experiences exactly how much people are willing to sacrifice for the family - both figurative and literal - as he investigates a series of strange events involving his loved ones. After serving a three-year prison sentence, the older and more cohesive Kiryu finds out that his surrogate daughter, Haruka, has disappeared from his orphanage.

The trail leads to his old area in Kamurocho, where he learns that she was hit by a car and is now in a coma. As if that were not enough, it turns out that Haruka has a son he is now forced to take care of. With the small child in his arms, he sets off for the coastal village of Onomichi in Hiroshima to reveal the truth about Haruka, her son and the unpleasant secret that Hiroshimas yakuza is holding.